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Synovial sarcoma Radiology

Synovial sarcomas detected at radiography typically appear as nonspecific, round to oval juxtaarticular soft-tissue masses. Calcification is identified in up to 30% of synovial sarcomas at radiography (, 1 43) (Figs, 2, 7,) Synovial sarcoma is the fourth most common type of soft-tissue sarcoma, accounting for 2.5%-10.5% of all primary soft-tissue malignancies worldwide. Synovial sarcoma most often affects the extremities (80%-95% of cases), particularly the knee in the popliteal fossa, of adolescents and young adults (15-40 years of age) Synovial sarcoma is the third most common soft-tissue sarcoma in adults, accounting for approximately 10% of soft-tissue sarcomas [ 1 ]. Men and women are affected equally, and the mean age at presentation is 32 years [ 2 ] MRI features of synovial sarcoma are of a well-defined heterogeneous soft tissue mass around joint, more specifically, near to the tendon, bursa or around the joint capsule. The triple sign is classically described in synovial sarcoma which is a mixture of high, intermediate and low signal regions within the mass seen on T2 weighted images Synovial sarcomas are usually first detected as painless growing masses. 14 Confirmation of the presence of a mass by radiography and MRI is usually performed prior to biopsy. 14 Definitive SS diagnosis is based on biopsy

Synovial sarcoma is the most common malignant nonrhabdomyosarcoma soft-tissue sarcoma in children. This article shows examples of synovial sarcoma in children and corresponding examples of benign mimics Synovial sarcoma is frequently misdiagnosed as a benign condition because of its often small size, slow growth, and well-defined appearance. This malignancy is driven by a translocation between.. Ossifying synovial sarcomas have characteristic spotty radio-opacities caused by focal calcifications (Pathol Res Pract 2009;205:195 Synovial sarcoma is often first noticed as a painless lump. If it is near a nerve, it might cause pain or numbness as it grows. Imaging: If you have symptoms of synovial sarcoma, your doctor will use scans such as X-ray, ultrasound, CT scan, and MRI to take pictures of the tumor

Synovial sarcoma of the head and neck region seems to carry a better prognosis than synovial sar-coma of the extremities, with 5-year survival rates ranging from 47% to 82% (7, 8). The CT and MR imaging appearance of synovial sarcomas of the head and the neck has been de-scribed in previous publications as most often wel Synovial Sarcoma. Frontal radiograph of the foot demonstrates a heavily calcified lesion which is arising from the dorsum of the foot between the 2nd and 3rd metatarsals (white arrows).. For this same photo without arrows, click her Synovial sarcoma is a mesenchymal spindle-cell tumor characterized by variable epithelial differentiation. Its chest wall localization represents a diagnostic challenge because of the diverse array of competing diagnosis and rarity of incidence Both biphasic and monophasic synovial sarcomas are usually intermediate grade (grade 2/3); however, both types can be high grade (grade 3/3). 3 Poorly differentiated synovial sarcomas are high-grade tumors. Though plain radiographs and CT may aid in the diagnosis, MRI is the imaging modality of choice for evaluating soft-tissue sarcomas

Imaging of Synovial Sarcoma with Radiologic-Pathologic

Synovial sarcoma is usually slow-growing, so it can be years before a definitive diagnosis is made. In some cases, synovial sarcoma initially is diagnosed incorrectly as arthritis or bursitis. Imaging methods that may be helpful include: Plain X-ray. In some cases, large areas of the tumor are marked or even outlined by calcifications Synovial sarcoma is a high grade, relatively rare neoplasm with an incidence of 2.57 per 100,000 population annually. In contrast to other soft tissue sarcomas, it has a tendency to arise in the extremities of young adults, between the ages of 15 and 40 years. 19 There is a marked predilection for the lower extremity Abstract Synovial sarcoma is a well-recognized soft tissue malignancy that typically arises in young adults. It is now generally accepted that its origin is likely from undifferentiated mesenchymal tissue with variable epithelial differentiation and a highly specific chromosomal translocation in more than 95% of cases Objectives: Synovial sarcomas commonly involve extremities. The purpose of this study was to systematically assess and describe the appearance of pathologically proven synovial sarcomas on conventional MR sequences, diffusion weighted imaging and dynamic contrast enhanced imaging

The above imaging findings are consistent with previous reports.8, 9 To the authors' knowledge, there were no reports concerning the multiphase CT imaging findings of pleuropulmonary synovial sarcoma. In the present series, the tumour showed no prolonged or delayed enhancement in the three cases that underwent multiphase imaging, which was an. Synovial sarcoma: MR imaging findings in 34 patients. AJR Am J Roentgenol. 1993 Oct. 161(4):827-30. . . van Rijswijk CS, Hogendoorn PC, Taminiau AH, Bloem JL. Synovial sarcoma: dynamic contrast.

Synovial sarcoma is one of the common malignant mesenchymal tumors, which usually occurs in the extremities of young adults [1, 2, 3].The radiological features of synovial sarcoma, including cyst formation, have been relatively well described [].However, there is limited information on the correlation with the clinicopathologic features [5, 6].We therefore report the radiological and. Synovial sarcoma is a rare cancer that is more commonly diagnosed in people under 40. It is a form of soft tissue sarcoma. Synovial sarcoma usually occurs in the arms and legs, but it can be diagnosed in all parts of the body and in people of all ages. Doctors use imaging to detect synovial sarcoma.

Synovial Sarcoma: Imaging Features of Common and Uncommon

is the gold standard for diagnostic imaging for synovial sarcoma (Figure 2) [17]. MRI de-Figure 1. AP (A) and lateral (B) radiographs of the right (R) knee and lower leg in a 31-year-old male demonstrate coarse calcifications within the soft tissues adjacent to the posteromedial tibial plateau, corresponding to a biopsy proven synovial sarcoma We evaluated magnetic resonance imaging (MRI) findings of synovial sarcomas in 22 patients, and the most common MRI findings were oval and well-defined nodular masses with heterogeneous intermediate signal intensity (SI) on T1 weighted images (WI), high SI on T2-WI and heterogeneous contrast enhancement Synovial sarcoma in the proximal forearm shows radiographically visible calcification ( left ).This is found in up to 30% of these tumors. Extrinsic bone erosion of the second metatarsal and cortical thickening of the third metatarsal is seen in this foot tumor ( right ).Periosteal reaction is seen in 11% to 20% of synovial sarcomas, and cortical erosion in 5% Objectives. Synovial sarcomas commonly involve extremities. The purpose of this study was to systematically assess and describe the appearance of pathologically proven synovial sarcomas on conventional MR sequences, diffusion weighted imaging and dynamic contrast enhanced imaging Synovial sarcoma. Synovial sarcoma is the fourth most common soft tissue sarcoma, 18-25% of which occur in the ankle and foot making it the most common malignancy in this region [14,15,16, 31]. Despite its name, it is in fact a lesion of mesenchymal origin and is named for its histological resemblance to synovial tissue [16, 31]

Synovial sarcoma Radiology Case Radiopaedia

  1. Bixby SD et al: Synovial sarcoma in children: imaging features and common benign mimics. AJR Am J Roentgenol. 195(4):1026-32, 2010. Lisle JW et al: Risk assessment based on FDG-PET imaging in patients with synovial sarcoma. Clin Orthop Relat Res. 467(6):1605-11, 2009. O'Sullivan PJ et al: Radiological features of synovial cell sarcoma
  2. Synovial sarcomas are a rare but aggressive malignancy that primarily affects young patients. Diagnosis is often difficult and delayed due to its insidious onset, heterogenous presentation and mimicry of other pathologies. We present the case of a patient with a history of a slow-growing left arm mass that arose after a traumatic fracture of the humerus. Multimodal imaging was undertaken and.
  3. Synovial sarcoma is very often associated with a grade 2 or grade 3. [ 12, 6, 7, 27] Punctuate areas of calcification may be observed. Staging requires local imaging with MRI. The most likely site of distant spread, the lungs, can be observed by means of CT. Synovial sarcoma is a high-grade lesion. Eilber FC, Dry SM

The present study retrospectively examined 24 cases of pathologically confirmed synovial sarcoma and analyzed the clinical presentation and imaging findings in order to explore the imaging features of synovial sarcoma. The majority of the lesions were large (>5 cm; 88%), rounded or lobulated, relatively well‑defined tumor masses in the extremities near the joints or deeply located On magnetic resonance imaging (MRI), synovial sarcoma displays an image that has been described as the triple signal pattern, which reflects a combination of calcifications, cystic changes due to necrosis and haemorrhage, and air fluid levels [12, 13] Objective. To determine whether previously described so-called malignant dynamic contrast-enhanced magnetic resonance (MR) imaging features - early start, peripheral enhancement and early plateau or washout phase - occur consistently in synovial sarcoma. Design and patients. Dynamic contrast-enhanced MR images of 10 patients with histologically proven synovial sarcoma were reviewed

Distinguishing synovial sarcoma from - Applied Radiolog

  1. Pleural synovial sarcoma (PSS) is a subtype comprising only 0.1%-0.5% of primary lung malignancies [2]. PSSs typically occur in adolescents and adults between the ages of 15 and 40 years without sex predilection. Symptoms can include dyspnoea, chest pain, and cough
  2. ations and the pathology results indicate the diagnosis of SS.
  3. Synovial sarcoma (shoulder joint) Peer Reviewed Pediatric Radiology Cases The Peer Reviewed Pediatric Radiology Platform on the Web ISSN: 1942-955X :: Publisher: EduRad ::Editor-In-Chief: Roland Talanow, MD, Ph
  4. e the incidence of intra-articular synovial sarcomas and investigate if any radiological variables can differentiate them from localized (unifocal) pigmented villonodular synovitis (PVNS) and if multivariate data analysis could be used as a complementary clinical tool. Methods. Magnetic resonance images and radiographs of 7 cases of intra-articular synovial sarcomas and 14.
  5. Synovial sarcoma is a soft tissue sarcoma. Its occurrence as a primary mediastinal neoplasm is very rare. We report a fatal case of mediastinal synovial sarcoma in a 14-year-old girl with exertive dy..
  6. Staging of synovial sarcoma involves cross-sectional imaging of the affected extremity, systematic staging with a chest CT, and pathologic assessment. The two most commonly utilized staging systems are the American Joint Committee on Cancer (AJCC) system and the Enneking staging system [ 26 , 27 ]
  7. Synovial sarcoma is the most common malignant soft tissue sarcoma in the foot, accounting for 18-22% of all such tumors. (9) In some series it is the single most common sarcoma of any type in the distal lower extremity. This tumor deserves extra attention and study for several reasons

Synovial Sarcoma in Children: Imaging Features and Common

Radiology: Synovial sarcoma of the abdominal wall: Imaging findings and review of the literature de Haas et al. rts Synovial sarcoma is the fourth most common type of soft (following undifferentiated pleomorphic sarcoma, liposarcoma, and rhabdomyosarcoma), and should be considered a high high number of local recurrences and late metastases.. Imaging studies such as x-ray, CT scan and/or MRI scan; Genetic testing to detect the specific chromosomal translocation between chromosome 18 and chromosome X that is identified in most cases of synovial sarcoma; A biopsy of the tumor; Medscape Reference's Web site offers more specific information regarding the diagnosis of synovial sarcoma. The purpose of this study is to evaluate the safety and effectiveness of AL3818 (catequentibub, anlotinib) hydrochloride in the treatment of metastatic or advanced alveolar soft part sarcoma (ASPS), leiomyosarcoma (LMS), and synovial sarcoma (SS). All participants with ASPS will receive open-label AL3818 Synovial sarcoma (SS) is a rare malignant neoplasm that arises most commonly in joint capsules and articular tendons, but its relationship to the synovium is not always obvious. Synovial sarcoma is a malignant soft tissue tumor representing 5.6% to 10% of all soft tissue sarcomas. They are termed SS because of their histologic resemblance to the synovium, but they rarely involve a synovial. Abstract: Soft tissue sarcoma of the hand is rare, with synovial sarcoma being among the most common pathological diagnoses. As postoperative radiation therapy for synovial sarcoma, a 22-year-old male patient was treated with a total dose of 60 Gy, administered in 30 daily fractions

Synovial sarcoma is a common soft tissue malignancy accounting for 5 - 10 % of soft tissue sarcomas. Patients with synovial cell sarcoma are often between the ages of 15 and 35 years old; generally younger than patients with other types of soft tissue sarcomas. The most probable cellular origin is an undifferentiated mesenchymal cell We studied the MR features of synovial sarcoma in 34 patients to determine if these tumors have specific MR findings that can be used to suggest the diagnosis. MATERIALS AND METHODS: MR imaging studies of 34 patients with synovial sarcoma were collected from two institutions and studied to determine the following characteristics of the tumor. Synovial sarcomas (SS) represent a unique subset of soft tissue sarcomas (STS) and account for 5-10% of all STS. Synovial sarcoma differs from other STS by the relatively young age at diagnosis and clinical presentation. Synovial sarcomas have unique genomic characteristics and are driven by a pathognomonic t(X;18) chromosomal translocation and subsequent formation of the SS18:SSX fusion. Synovial sarcoma mostly affects the limbs, and in order for the surgeon to achieve these margins in this area of the body some patients will receive limb-sparing surgery. This is where the affected bone is taken out and then replaced with a specially designed metal replacement (prosthesis) or bone graft (bone taken from another part of the body)

We report on a 23-year-old woman with a poorly differentiated synovial sarcoma on the palm of her hand which presented as a painless nodule. The MRI findings are presented along with the clinical and pathologic features. Becaue of similar morphological features, these tumors can be confused with benign lesions such as aggressive fibromatosis or ganglion cysts, especially when very small. The. CT scan will detect the location of the tumor and will show the local invasion or distant metastasis. Magnetic resonance imaging is considered a better imaging tool than a CT scan, as it provides higher resolution and can detect invasion of the myocardium . Very few cases of synovial sarcoma have been reported in the past Primary synovial sarcomas are most common in the soft tissue near the large joints of the arm and leg, but has been found in most human tissues and organs, including the brain, prostate, and heart. Synovial sarcoma occurs most commonly in the younger patients under 30 years of age. While overall comprising about 8% of all soft tissue sarcomas.

1 Introduction. Synovial sarcoma (SS) is a rare type of cancer, which occurs in 5% to 10% of soft tissues. It tends to arise the most frequently in the lower limbs of the body. However, tumors may develop in other parts of the body, that is, head, neck, trunk, and pelvis. Primary renal synovial sarcoma (PRSS) is rarer compared with SS.. SS typically occurs in young adults and has a poor. Diagnosis and Radiology. Synovial sarcoma may be diagnosed through various imaging studies like radiographic examination, ultrasound, computed tomography (CT scan) and magnetic resonance imaging (MRI). These imaging studies would be helpful in determining the size and location of the tumor Synovial sarcoma (SS) is a rare type of cancer. It affects soft tissues, which connect, support, and surround bones and organs in your body. These may include muscle, fat, blood or lymph vessels. Bernreuter WK, Sartoris DJ, Resnick D: Magnetic resonance imaging of synovial sarcoma. J Foot Surg 29:94- ,1990. Ben Arush MW, Ben Arieh Y, Bialik V, Goldsher D, Meller I, Berant M: Synovial sarcoma associated with osteofibrous dysplasia. A case report and review of the literature. Am J Pediatr Hematol Oncol 14:261-4,1992 Synovial Sarcoma of Lung is a rare malignancy of the lung. However, the lung is the most frequently involved 'organ' by synovial sarcoma. The tumor is mostly observed as a nodule in the lung periphery. The tumors can be locally infiltrative and cause obstructive signs and symptoms including chest pain and breathing difficulties

thoracic paravertebral synovial sarcoma in an adult male. Thus, we report the case of a 60-year-old man with a mono-phasic synovial sarcoma at T7-T10 who had plain radiog-raphy, bone scintigraphy, magnetic resonance imaging (MRI), and computed tomography (CT) as well as intrao-perative and histopathologic correlation. The patient wa A most recent review on Global Synovial Sarcoma Treatment Market is led covering different associations of the business from various topographies to think of 100+ page report.The examination is an ideal blend of subjective and quantitative data featuring key market improvements, challenges that industry and rivalry is looking alongside whole investigation and new open door accessible and may. Researchers yield new insights into origins of synovial sarcoma. A new study published today in Cancer Discovery, a journal of the American Association for Cancer Research, reports findings that. Radiological imaging of pleuropulmonary synovial sarcoma Section. Chest imaging . Case Type. Clinical Cases Authors. Kotoula A 1, Kontogounis G 2, Xinou E 1, Koffas J 1, Giannopoulos P 1. 1) Radiology Department, Theagenion Anticancer Research Hospital; 2) AHEPA University hospital Synovial cell sarcoma is the most common malignant nonrhabdomyosarcoma soft-tissue sarcoma in children. Synovial cell sarcoma does not arise from the synovial membrane, and takes its name from the histological similarity of the cells to synovioblastic cells. This blog is intended for radiology professionals and contains non-peer reviewed.

Synovial Sarcoma Imaging: Practice Essentials, Radiography

Synovial sarcoma of the hand. Synovial sarcoma is a relatively common tumor, representing 5-10% of all soft tissue sarcoma. [31,32] It is intermediate to high-grade malignancy with high metastatic potential. Irrespective of the nomenclature, neither does it arise from the synovium nor does it express synovial markers Imaging of synovial sarcoma (abstract). Radiology 1998;209(P):421. 19. Smith TA, Machen SK, Fisher C, et al. Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from. Synovial sarcoma Introduction: 10% of all primary soft-tissue malignant tumors Most commonly seen inknee Does not arise from synovial membrane! but from primitive mesenchymal cells in extraarticular soft tissues MRI in orthopaedics and sports medicine. 3rd edition. Lippincott Williams and Wilkins publications. 2007 Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma and rarely occurs primarily in bone. However, only few studies have been reported on intraosseous synovial sarcoma, and reports on cases with cytogenetic or molecular confirmation are even. Importance Synovial cell sarcoma of the head and neck (SCSHN) is a rare tumor associated with significant morbidity and mortality. The literature regarding these tumors is limited to case series and case reports. We used data from the population-based US Surveillance, Epidemiology, and End Results (SEER) cancer registry to determine factors affecting both overall survival and disease-specific.

Synovial Sarcoma. - See: Soft Tissue Tumor Menu. - Discussion: - 4th most common soft-tissue sarcoma (5 to 10 percent of all cases of soft-tissue sarcoma) - tumor derived from the synovial tissues found along fascial planes, periarticular structures, and rarely, in joints; - it may involve the sheaths and bursae of the tendons; - presentation MRI (magnetic resonance imaging) MRI uses radio waves and strong magnets instead of x-rays to take pictures of the body. MRI scans are often part of the work-up of any tumor that could be a sarcoma. They're often better than CT scans in evaluating sarcomas in the arms or legs. MRI provides a good picture of the extent of the tumor The novel SS18-SSX fusion-specific antibody is reported to have high sensitivity and specificity for the diagnosis of primary synovial sarcoma (SS), which often metastasizes to the lung. Thus far, no study has validated the diagnostic efficacy of SS18-SSX antibody for pulmonary metastatic SS. Therefore, we aimed to investigate the usefulness of the SS18-SSX antibody in the diagnosis of. Malignant tumors include synovial sarcoma and soft tissue sarcoma. Knee joint is the most common site for majority of these soft tissue tumors. These tumors being superficial are usually felt on clinical examination and imaging is necessary to evaluate its morphology, extent, differential diagnosis and post operative follow-up Synovial sarcoma: dynamic contrast-enhanced MR imaging features Synovial sarcoma: dynamic contrast-enhanced MR imaging features van Rijswijk, C. S. P.; Hogendoorn, P. C. W.; Taminiau, A. H. M.; Bloem, J. L. 2001-02-01 00:00:00 Objective. To determine whether previously described so-called malignant dynamic contrast-enhanced magnetic resonance (MR) imaging features - early start, peripheral.

Pathology Outlines - Synovial sarcom

The aim of this article is to describe the key magnetic resonance imaging (MRI) features of SS, as well as to describe those of benign and malignant tumors that are often confused with SS (Table 1). In one study, 84% of synovial sarcoma patients were between 10 and 50 years old. (5) Males and females seem to be equally affected Synovial sarcoma (monophasic fibrous type) Imaging Findings: A large irregular lesion demonstrating heterogeneous signal intensity is demonstrated in the region of left supraspinatus muscle. Foci of spared enhancement are noted within the body of the tumor, correlating with areas of necrosis and lending the lesion an appearance of. The study from Van Tine and colleagues tested ADP-A2M4 SPEAR T cells to target MAGE-A4 in 16 patients with advanced synovial sarcoma. Lymphodepletion consisted of cyclophosphamide (600 mg/m 2.

Synovial Sarcoma - National Cancer Institut

Sarcomas are treated by specialists, depending on where the sarcoma is located. In larger medical centers, sarcomas are treated by a team of caregivers, including surgeons, radiologists, medical oncologists (cancer specialists), radiation oncologists, pathologists, pediatric specialists (for cancers in children), psychologists and social workers mary intraosseous synovial sarcoma of the jaw [5, 6], and a case series of sacral synovial sarcoma were re-ported [7]; however, details of their imaging and histo-logic findings were unclear. To the best of our knowledge, our case is only the seventh reported case of intraosseous synovial sarcoma that has been confirmed using molecular analysis

LearningRadiology - synovioma, synovial, sarcoma, neoplasm

Synovial sarcomas are most commonly localised in extremities, especially in the lower thigh and knee areas. Comprising less than 1% of all malignancies, retroperitoneal synovial sarcoma is very rare with primary synovial sarcoma of the kidney being even more infrequent and difficult to diagnose. We describe a case report of a renal synovial sarcoma in a young adult who was initially managed as. Synovial sarcoma (SS) is a spindled cell sarcoma demonstrating varying degrees of epithelial differentiation and characterized by a pathognomonic t(X;18) translocation. SS most frequently involves deep soft tissue of the extremities in young adults. Superficial SS involving dermis and/or subcutaneous tissue is exceedingly rare. Methods and result

Synovial sarcoma of the chest wall: a case report and

Despite the fact that synovial sarcoma (SS) is a rare disease, it is the second most common type of soft tissue sarcoma (STS) in children and adolescents after rhabdomyosarcoma. This subtype of neoplasms affects both children and adults, with its peak incidence occurring in the third decade of life. 1 Despite its name, SS can develop anywhere. Background:A synovial sarcoma arising from the kidney is extremely rare. To date, few data are available on their radiological features.Purpose:To identify the computer tomography (CT) imaging find.. Synovial sarcoma is a soft tissue sarcoma. About one to three people in a million are diagnosed with the disease each year. Synovial sarcoma can occur at any age, but is most common in teens and young adults. It is more common in males than females An extremely rare soft tissue cancer, synovial sarcoma, deformed the facial features of a young golfer. Tim, from Michigan, USA, experienced severe jaw pain. After a series of investigations including magnetic resonance imaging (MRI), Tim got a diagnosis of synovial sarcoma. Initially, MRI had shown an egg-sized tumour Prognosis for synovial sarcoma. The prognosis for synovial sarcoma is unfavorable. Thus, the five-year survival of patients diagnosed with synovial sarcoma is 20-30%. Treatment of tumors involves the use of surgical methods, methods of chemotherapy and radiation exposure

Article - Synovial sarcoma - Applied Radiolog

Symptoms of a Synovial Sarcoma. Symptoms of sarcoma in the foot and ankle vary. In some cases, the sarcoma is a visible lump and can look much like a benign ganglion cyst. The mass may have been slowly growing for months, years, or even decades. Some sarcomas cause no pain while others are painful right from the outset Christina's Story | Synovial Sarcoma at the Femur. Christina was 22 when she was diagnosed with synovial sarcoma at the femur. Her treatment included surgery, radiation therapy and chemotherapy Radiology included 2 computed tomography studies, 1 magnetic resonance imaging study, and 1 case with fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography images. Findings were similar to typical pulmonary synovial sarcoma as previously reported Figure 1 [9]

Synovial sarcoma of foot | Image | RadiopaediaPrimary giant mediastinal synovial sarcoma of the neck: A

Catequentinib is effective for the treatment of patients with synovial sarcoma, said Van Tine in concluding his presentation at the American Society of Clinical Oncology (ASCO) virtual meeting. This finding is further supported an additional study of 1,240 patients from the French Federation of Cancer Centers Sarcoma Group which found that histologic grade was prognostic in MFH, unclassified sarcomas, synovial sarcomas, LMS, and LPS, but not in other STS subtypes . Thus, using histologic grade as the primary variable to craft. Diagnosis of the synovial sarcoma involves imaging of the affected area, biopsy, genetic testing, and bone scans. Treatment of the synovial sarcoma involves a few approaches ranging from. Afami-cel is a specific peptide enhanced affinity receptor (SPEAR) T-cell therapy that is engineered to target MAGE-A4 peptide expressed on tumor cells. In the context of HLA-A*02, MAGE-A4 is highly expressed in synovial sarcoma and MRCLS. 2 The T-cell therapy previously demonstrated clinical activity in in various tumors in a phase 1 study. Synovial Sarcoma of Stomach is an extremely uncommon and malignant mesenchymal (non-epithelial) tumor. The tumor is predominantly seen in younger populations (children and teenagers) The cause of formation of this gastric tumor may be due to genetic and chromosomal abnormalities. No definitive risk factors are observed for Synovial Sarcoma of. Synovial sarcoma (SS) is a morphologically, clinically, and genetically well-defined soft-tissue neoplasm. SSs are characterized by the t(X;18)(p11.2;q11.2) translocation, which leads to SS18-SSX gene fusion [1, 2], and extremely rare neoplasms harbor SS18L1-SSX1, resulting from t(X;20) [3, 4].Most tumors occur in the extremities near the joints, followed by the trunk and head and neck regions.